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The air ow generated by inhalation directly determines particle velocity and hence the ease with which particles are deagglomerated The materials used in the construction of DPIs and the characteristics of the formulation affect electrostatic charge accumulation Some formulations as well as inhaler materials accumulate and retain electrostatic charge more strongly than others, and this will affect both drug retention within these inhalers as well as delivered aerosol behavior [166] Pulmozyme , recombinant deoxyrucleic acid (DNA) derived human DNase I (rhDNase) has been formulated for local delivery to the lung by inhalation rhDNase was lled originally in glass vials for clinical studies A direct stability comparison study was made between rhDNase in glass vials and rhDNase lled into plastic ampoules using the blow- ll seal technology of Alp, which uses low-density polyethylene resins which are gas permeable.

Figure 9.7. Minimum spot size of the output beam focused by a lens with a 40-mm focal length. The drive current is 2ith.

Often you need to open an existing drawing, either to complete it or to make changes. Opening a drawing in AutoCAD or AutoCAD LT is like opening a file in any Windows program. You can find existing drawings by name or by viewing a thumbnail, or preview image, of the drawing. Choose Open from the Standard toolbar. The Select File dialog box appears, as shown in Figure 2-3. In the Look in drop-down list box, choose the drive where your drawing resides. In the main box, double-click the folder you need. Then choose your drawing. The

access flow control, 253 bandwidth allocation, 253 255 BBFC algorithm, 246 249 buffer overflow prevention, 252 control objectives, 243 246 data starvation avoidance, 252 253 dequeue process, 256 quantum refreshment, 255 256 rate updating algorithm, 249 251 service policy, 253 256 simulation results, 256 263 virtual channel flow dynamics, 242 243 service categories, 240 242 packet fair queuing PFQ. algorithm, shaper-schedulers, 155 156 quality of service QoS. parameters, 7 8, 13 quality of service QoS. routing, 300 316 PNNI signaling, 306 316 user-to-network UNI. signaling, 301 306 service categories, 2 4, 8, 240 242 shaping multiplexer, traffic access control, 66 90 departure-event-driven traffic shaping algorithm, 72 73 DT calculation and bucket level update, 73 77 finite bit overflow, 78 86 implementation architecture, 77 78 readout procedure, 78 timing processor, 77 write-in procedure, 77 78 regularity condition-dual leaky bucket, 67 70 shaping and scheduling algorithm, 71 72 simulation study, 86 89 SONET protocol: AAL properties, 395 396 AAL types 3r4, 404 406 AAL type 1, 401 403 AAL type 2, 403 404 AAL type 5, 406 407 adaptation layer, 399 401 ATM protocol reference model, 379 380 automatic protection switching APS., 389 391 cell loss priority, 398 frequency justification, 388 389 OC-N multiplexor, 392 393 overhead bytes, 385 387 payload identifier, 397 398 predefined header field values, 398 399 research background, 377 379 scrambling and descrambling, 387 388 STS-N signals, 382 385

The problem of gas permeation was addressed by packing the plastic ampoules in a gas-impermeable foil pouch which can be lled with nitrogen The rate of deamindation was similar for rhDNase stored at 2 8 C in foiled and unfoiled ampoules but substantially different from protein stored in glass vials This difference in deamidation rate was attributed to the 05unit difference in pH of rhDNase in glass (due to leaching of ions, possibly sodium, from the glass surface) versus plastic ampoules This result provided the rationale for the choice of container closure component for rhDNase aerosols [167] Improvements in the design of pMDIs has facilitated the extension of pMDIs to administering macromolecules such as peptides and proteins The belief is that the HFA environment within the pMDI is inert and essentially moisture free, thereby providing good stability for macromolecules.

Tip You can modify more than one layer at a time. In the Layer Properties Manager, right-click and choose Select All to choose all of the layers. Choose Clear All to deselect all of the layers. You can choose a range of layers by clicking the first layer in the range, pressing Shift, and clicking the last layer in the range. Finally, you can choose individual layers by pressing Ctrl for each additional layer. Changes that you make to color, linetype, or lineweight affect all of the selected layers.